Acquired resistance to immunotherapy and future challenges

NP Restifo, MJ Smyth, A Snyder - Nature Reviews Cancer, 2016 - nature.com
NP Restifo, MJ Smyth, A Snyder
Nature Reviews Cancer, 2016nature.com
Advances in immunotherapy have resulted in remarkable clinical responses in some
patients. However, one of the biggest challenges in cancer therapeutics is the development
of resistant disease and disease progression on or after therapy. Given that many patients
have now received various types of immunotherapy, we asked three scientists to give their
views on the current evidence for whether acquired resistance to immunotherapy exists in
patients and the future challenges posed by immunotherapy.
Abstract
Advances in immunotherapy have resulted in remarkable clinical responses in some patients. However, one of the biggest challenges in cancer therapeutics is the development of resistant disease and disease progression on or after therapy. Given that many patients have now received various types of immunotherapy, we asked three scientists to give their views on the current evidence for whether acquired resistance to immunotherapy exists in patients and the future challenges posed by immunotherapy.
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