[HTML][HTML] The mechanisms by which both heterozygous peroxisome proliferator-activated receptor γ (PPARγ) deficiency and PPARγ agonist improve insulin resistance

T Yamauchi, J Kamon, H Waki, K Murakami… - Journal of Biological …, 2001 - ASBMB
Peroxisome proliferator-activated receptor (PPAR) γ is a ligand-activated transcription factor
and a member of the nuclear hormone receptor superfamily that is thought to be the master
regulator of fat storage; however, the relationship between PPARγ and insulin sensitivity is
highly controversial. We show here that supraphysiological activation of PPARγ by PPARγ
agonist thiazolidinediones (TZD) markedly increases triglyceride (TG) content of white
adipose tissue (WAT), thereby decreasing TG content of liver and muscle, leading to …