Expression of PPARγ in eosinophils and its functional role in survival and chemotaxis
S Ueki, T Adachi, J Bourdeaux, H Oyamada… - Immunology …, 2003 - Elsevier
Eosinophils play a pivotal role in the mechanism of allergic diseases including asthma.
Interleukin-5 (IL-5) and eotaxin are critical cytokines/chemokines for eosinophil activation.
Peroxisome proliferator-activated receptor γ (PPARγ) is a nuclear receptor that regulates
lipid metabolism. Recent evidence has suggested that PPARγ serves as a negative
regulator in the immune system. In the present study, we investigated the expression of
PPARγ and effect of PPARγ agonist on human eosinophils. We demonstrated that purified …
Interleukin-5 (IL-5) and eotaxin are critical cytokines/chemokines for eosinophil activation.
Peroxisome proliferator-activated receptor γ (PPARγ) is a nuclear receptor that regulates
lipid metabolism. Recent evidence has suggested that PPARγ serves as a negative
regulator in the immune system. In the present study, we investigated the expression of
PPARγ and effect of PPARγ agonist on human eosinophils. We demonstrated that purified …