H3K27 methylation: a focal point of epigenetic deregulation in cancer
JN Nichol, D Dupéré-Richer, T Ezponda… - Advances in cancer …, 2016 - Elsevier
Epigenetics, the modification of chromatin without changing the DNA sequence itself,
determines whether a gene is expressed, and how much of a gene is expressed.
Methylation of lysine 27 on histone 3 (H3K27me), a modification usually associated with
gene repression, has established roles in regulating the expression of genes involved in
lineage commitment and differentiation. Not surprisingly, alterations in the homeostasis of
this critical mark have emerged as a recurrent theme in the pathogenesis of many cancers …
determines whether a gene is expressed, and how much of a gene is expressed.
Methylation of lysine 27 on histone 3 (H3K27me), a modification usually associated with
gene repression, has established roles in regulating the expression of genes involved in
lineage commitment and differentiation. Not surprisingly, alterations in the homeostasis of
this critical mark have emerged as a recurrent theme in the pathogenesis of many cancers …