Contribution of afferent pathways to nerve injury-induced spontaneous pain and evoked hypersensitivity
T King, C Qu, A Okun, R Mercado, J Ren, T Brion, J Lai… - Pain, 2011 - Elsevier
A predominant complaint in patients with neuropathic pain is spontaneous pain, often
described as burning. Recent studies have demonstrated that negative reinforcement can
be used to unmask spontaneous neuropathic pain, allowing for mechanistic investigations.
Here, ascending pathways that might contribute to evoked and spontaneous components of
an experimental neuropathic pain model were explored. Desensitization of TRPV1-positive
fibers with systemic resiniferatoxin (RTX) abolished spinal nerve ligation (SNL) injury …
described as burning. Recent studies have demonstrated that negative reinforcement can
be used to unmask spontaneous neuropathic pain, allowing for mechanistic investigations.
Here, ascending pathways that might contribute to evoked and spontaneous components of
an experimental neuropathic pain model were explored. Desensitization of TRPV1-positive
fibers with systemic resiniferatoxin (RTX) abolished spinal nerve ligation (SNL) injury …