[HTML][HTML] A look at autoimmunity and inflammation in the eye

RR Caspi - The Journal of clinical investigation, 2010 - Am Soc Clin Investig
The Journal of clinical investigation, 2010Am Soc Clin Investig
Autoimmune and inflammatory uveitis are a group of potentially blinding intraocular
inflammatory diseases that arise without a known infectious trigger and are often associated
with immunological responses to unique retinal proteins. In the United States, about 10% of
the cases of severe visual handicap are attributed to this group of disorders. As I discuss
here, experimental models of ocular autoimmunity targeting retinal proteins have brought
about a better understanding of the basic immunological mechanisms involved in the …
Autoimmune and inflammatory uveitis are a group of potentially blinding intraocular inflammatory diseases that arise without a known infectious trigger and are often associated with immunological responses to unique retinal proteins. In the United States, about 10% of the cases of severe visual handicap are attributed to this group of disorders. As I discuss here, experimental models of ocular autoimmunity targeting retinal proteins have brought about a better understanding of the basic immunological mechanisms involved in the pathogenesis of uveitis and are serving as templates for the development of novel therapies.
The Journal of Clinical Investigation