Morphine versus Mexiletine for Treatment of Postamputation Pain: A Randomized, Placebo-controlled, Crossover Trial
CL Wu, S Agarwal, PK Tella, B Klick… - The Journal of the …, 2008 - pubs.asahq.org
Background Stump and phantom pains are debilitating sequelae of amputations that are
often resistant to treatment. The efficacy of pharmacologic therapies, including opioids and
sodium channel blockers, for postamputation pain is uncertain. Methods The authors
conducted a double-blind, randomized, placebo-controlled, crossover study in adult patients
with postamputation pain of 6 months or longer and greater than 3 on a 0-10 numeric pain
rating scale. Each of the three treatment periods (morphine, mexiletine, or placebo) included …
often resistant to treatment. The efficacy of pharmacologic therapies, including opioids and
sodium channel blockers, for postamputation pain is uncertain. Methods The authors
conducted a double-blind, randomized, placebo-controlled, crossover study in adult patients
with postamputation pain of 6 months or longer and greater than 3 on a 0-10 numeric pain
rating scale. Each of the three treatment periods (morphine, mexiletine, or placebo) included …