The effects of different aspirin dosing frequencies and the timing of aspirin intake in primary and secondary prevention of cardiovascular disease: a systematic review

D Bem, M Lordkipanidzé, J Hodgkinson… - Clinical …, 2016 - Wiley Online Library
D Bem, M Lordkipanidzé, J Hodgkinson, S Stevens, S Bayliss, D Moore, D Fitzmaurice…
Clinical Pharmacology & Therapeutics, 2016Wiley Online Library
Enhancing the effectiveness of aspirin by tailoring administration regimens is an important
question among health professionals. We conducted a systematic review to evaluate the
evidence on the effects of different aspirin regimens in terms of timing (chronotherapy) or
frequency of dosing in the prevention of cardiovascular disease. Only two out of the 28
included studies reported long‐term cardiovascular outcomes, highlighting an evidence gap
that future research should address. The remaining 26 studies used surrogate outcomes.
Enhancing the effectiveness of aspirin by tailoring administration regimens is an important question among health professionals. We conducted a systematic review to evaluate the evidence on the effects of different aspirin regimens in terms of timing (chronotherapy) or frequency of dosing in the prevention of cardiovascular disease. Only two out of the 28 included studies reported long‐term cardiovascular outcomes, highlighting an evidence gap that future research should address. The remaining 26 studies used surrogate outcomes.
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