PURPOSE: Nocturnal hypertension is associated with a high risk of morbidity and mortality.
A blunted nocturnal surge in melatonin excretion has been described in nondipping
hypertensive patients. We therefore studied the potency of melatonin to reduce nighttime
blood pressure (BP) in treated hypertensive patients with nocturnal hypertension. PATIENTS
AND METHODS: Thirty-eight treated hypertensive patients (22 males, mean age 64±11
years) with confirmed nocturnal hypertension (mean nighttime systolic BP> 125 mm Hg) …