[HTML][HTML] Nontransgenic models of breast cancer

GH Heppner, FR Miller, PV Malathy Shekhar - Breast Cancer Research, 2000 - Springer
GH Heppner, FR Miller, PV Malathy Shekhar
Breast Cancer Research, 2000Springer
Numerous models have been developed to address key elements in the biology of breast
cancer development and progression. No model is ideal, but the most useful are those that
reflect the natural history and histopathology of human disease, and allow for basic
investigations into underlying cellular and molecular mechanisms. We describe two types of
models: those that are directed toward early events in breast cancer development
(hyperplastic alveolar nodules [HAN] murine model, MCF10AT human xenograft model); …
Abstract
Numerous models have been developed to address key elements in the biology of breast cancer development and progression. No model is ideal, but the most useful are those that reflect the natural history and histopathology of human disease, and allow for basic investigations into underlying cellular and molecular mechanisms. We describe two types of models: those that are directed toward early events in breast cancer development (hyperplastic alveolar nodules [HAN] murine model, MCF10AT human xenograft model); and those that seek to reflect the spectrum of metastatic disease (murine sister cell lines 67, 168, 4T07, 4T1). Collectively, these models provide cell lines that represent all of the sequential stages of progression in breast disease, which can be modified to test the effect of genetic changes.
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