The role of differential expression of human interferon-A genes in antiviral immunity

P Génin, A Vaccaro, A Civas - Cytokine & growth factor reviews, 2009 - Elsevier
Immune recognition of virus-associated molecules by Toll-like receptors (TLRs) and/or RIG-I-
like receptors (RLRs) triggers intracellular signaling cascades that converge on the
activation of interferon regulatory factors–particularly IRF3 and IRF7, leading to the
transcriptional induction of type 1 interferon genes. This review summarizes new data
describing how these factors regulate the temporal and quantitative differences in the
expression of the multigenic IFN-A family. The distinctive DNA-binding features of IRF3 and …