Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob …

Y Namba, M Tomonaga, H Kawasaki, E Otomo, K Ikeda - Brain research, 1991 - Elsevier
Y Namba, M Tomonaga, H Kawasaki, E Otomo, K Ikeda
Brain research, 1991Elsevier
During the course of our immunohistochemical studies on the change of lipids in Alzheimer's
disease brains by using antibody to apolipoprotein E, a protein having a special relevance
to nervous tissue, we unexpectedly found that apo E immunoreactivity was associated with
amyloid in both senile plaques and cerebral vessels and neurofibrillary tangles. The
immunoreactivity was also found in amyloid of kuru plaques in Creutzfeldt-Jakob disease.
Pretreatment of the sections with formic acid greatly enhanced immunoreactivity of senile …
Abstract
During the course of our immunohistochemical studies on the change of lipids in Alzheimer's disease brains by using antibody to apolipoprotein E, a protein having a special relevance to nervous tissue, we unexpectedly found that apo E immunoreactivity was associated with amyloid in both senile plaques and cerebral vessels and neurofibrillary tangles. The immunoreactivity was also found in amyloid of kuru plaques in Creutzfeldt-Jakob disease. Pretreatment of the sections with formic acid greatly enhanced immunoreactivity of senile and kuru plaques to antibody to apo E.
Elsevier