[HTML][HTML] Deletion of Abca1 increases Aβ deposition in the PDAPP transgenic mouse model of Alzheimer disease

SE Wahrle, H Jiang, M Parsadanian… - Journal of Biological …, 2005 - ASBMB
Apolipoprotein E (apoE) genotype has a major influence on the risk for Alzheimer disease
(AD). Different apoE isoforms may alter AD pathogenesis via their interactions with the
amyloid β-peptide (Aβ). Mice lacking the lipid transporter ABCA1 were found to have
markedly decreased levels and lipidation of apoE in the central nervous system. We
hypothesized that if Abca1-/-mice were bred to the PDAPP mouse model of AD, PDAPP
Abca1-/mice would have a phenotype similar to that of PDAPP Apoe+/-and PDAPP Apoe …