[HTML][HTML] The extracellular matrix in myocardial injury, repair, and remodeling

NG Frangogiannis - The Journal of clinical investigation, 2017 - Am Soc Clin Investig
The Journal of clinical investigation, 2017Am Soc Clin Investig
The cardiac extracellular matrix (ECM) not only provides mechanical support, but also
transduces essential molecular signals in health and disease. Following myocardial
infarction, dynamic ECM changes drive inflammation and repair. Early generation of
bioactive matrix fragments activates proinflammatory signaling. The formation of a highly
plastic provisional matrix facilitates leukocyte infiltration and activates infarct myofibroblasts.
Deposition of matricellular proteins modulates growth factor signaling and contributes to the …
The cardiac extracellular matrix (ECM) not only provides mechanical support, but also transduces essential molecular signals in health and disease. Following myocardial infarction, dynamic ECM changes drive inflammation and repair. Early generation of bioactive matrix fragments activates proinflammatory signaling. The formation of a highly plastic provisional matrix facilitates leukocyte infiltration and activates infarct myofibroblasts. Deposition of matricellular proteins modulates growth factor signaling and contributes to the spatial and temporal regulation of the reparative response. Mechanical stress due to pressure and volume overload and metabolic dysfunction also induce profound changes in ECM composition that contribute to the pathogenesis of heart failure. This manuscript reviews the role of the ECM in cardiac repair and remodeling and discusses matrix-based therapies that may attenuate remodeling while promoting repair and regeneration.
The Journal of Clinical Investigation