Propofol Depresses Angiotensin II–induced Cell Proliferation in Rat Cardiac Fibroblasts
TH Cheng, YM Leung, CW Cheung… - The Journal of the …, 2010 - pubs.asahq.org
Background Propofol may have beneficial effects on the prevention of angiotensin II (Ang II)-
induced cardiac fibroblast proliferation via its antioxidative properties. The authors
hypothesized that propofol may alter Ang II-induced cell proliferation and aimed to identify
the putative underlying signaling pathways in rat cardiac fibroblasts. Methods Cultured rat
cardiac fibroblasts were pretreated with propofol then stimulated with Ang II; cell proliferation
and endothelin-1 gene expression were examined. The effect of propofol on Ang II-induced …
induced cardiac fibroblast proliferation via its antioxidative properties. The authors
hypothesized that propofol may alter Ang II-induced cell proliferation and aimed to identify
the putative underlying signaling pathways in rat cardiac fibroblasts. Methods Cultured rat
cardiac fibroblasts were pretreated with propofol then stimulated with Ang II; cell proliferation
and endothelin-1 gene expression were examined. The effect of propofol on Ang II-induced …