Ventricular remodeling after infarction and the extracellular collagen matrix: when is enough enough?

BI Jugdutt - Circulation, 2003 - Am Heart Assoc
BI Jugdutt
Circulation, 2003Am Heart Assoc
Second, fibroblasts and myofibroblasts (myoFbs) 18 produce most of the matrix
macromolecules, including collagen, the principal structural protein. 36, 40 Third, the
collagen molecules consist of a central core of long, stiff, triple-stranded helices in which 3 α
chains wind around each other to form a superhelix. 40 Of the many collagen types (Table
5), the major fibrillar collagens are types I and III, which constitute the bulk of cardiac ECCM.
20 Thus, 85% of total collagen is type I, 40 which is associated mainly with thick fibers that …
Second, fibroblasts and myofibroblasts (myoFbs) 18 produce most of the matrix macromolecules, including collagen, the principal structural protein. 36, 40 Third, the collagen molecules consist of a central core of long, stiff, triple-stranded helices in which 3 α chains wind around each other to form a superhelix. 40 Of the many collagen types (Table 5), the major fibrillar collagens are types I and III, which constitute the bulk of cardiac ECCM. 20 Thus, 85% of total collagen is type I, 40 which is associated mainly with thick fibers that confer tensile strength and resistance to stretch and deformation, whereas 11% of total collagen is type III, 40 which is associated with thin fibers that confer resilience. The other matrix components also mediate important functions (Table
Am Heart Assoc