[HTML][HTML] Imaging the DNA damage response with PET and SPECT

JC Knight, S Koustoulidou, B Cornelissen - European journal of nuclear …, 2017 - Springer
JC Knight, S Koustoulidou, B Cornelissen
European journal of nuclear medicine and molecular imaging, 2017Springer
DNA integrity is constantly challenged by endogenous and exogenous factors that can alter
the DNA sequence, leading to mutagenesis, aberrant transcriptional activity, and cytotoxicity.
Left unrepaired, damaged DNA can ultimately lead to the development of cancer. To
overcome this threat, a series of complex mechanisms collectively known as the DNA
damage response (DDR) are able to detect the various types of DNA damage that can occur
and stimulate the appropriate repair process. Each DNA damage repair pathway leads to …
Abstract
DNA integrity is constantly challenged by endogenous and exogenous factors that can alter the DNA sequence, leading to mutagenesis, aberrant transcriptional activity, and cytotoxicity. Left unrepaired, damaged DNA can ultimately lead to the development of cancer. To overcome this threat, a series of complex mechanisms collectively known as the DNA damage response (DDR) are able to detect the various types of DNA damage that can occur and stimulate the appropriate repair process. Each DNA damage repair pathway leads to the recruitment, upregulation, or activation of specific proteins within the nucleus, which, in some cases, can represent attractive targets for molecular imaging. Given the well-established involvement of DDR during tumorigenesis and cancer therapy, the ability to monitor these repair processes non-invasively using nuclear imaging techniques may facilitate the earlier detection of cancer and may also assist in monitoring response to DNA damaging treatment. This review article aims to provide an overview of recent efforts to develop PET and SPECT radiotracers for imaging of DNA damage repair proteins.
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