L-selectin-negative CCR7 effector and memory CD8+ T cells enter reactive lymph nodes and kill dendritic cells

G Guarda, M Hons, SF Soriano, AY Huang… - Nature …, 2007 - nature.com
G Guarda, M Hons, SF Soriano, AY Huang, R Polley, A Martín-Fontecha, JV Stein
Nature immunology, 2007nature.com
T lymphocytes lacking the lymph node–homing receptors L-selectin and CCR7 do not
migrate to lymph nodes in the steady state. Instead, we found here that lymph nodes
draining sites of mature dendritic cells or adjuvant inoculation recruited L-selectin-negative
CCR7− effector and memory CD8+ T cells. This recruitment required CXCR3 expression on
T cells and occurred through high endothelial venules in concert with lumenal expression of
the CXCR3 ligand CXCL9. In reactive lymph nodes, recruited T cells established stable …
Abstract
T lymphocytes lacking the lymph node–homing receptors L-selectin and CCR7 do not migrate to lymph nodes in the steady state. Instead, we found here that lymph nodes draining sites of mature dendritic cells or adjuvant inoculation recruited L-selectin-negative CCR7 effector and memory CD8+ T cells. This recruitment required CXCR3 expression on T cells and occurred through high endothelial venules in concert with lumenal expression of the CXCR3 ligand CXCL9. In reactive lymph nodes, recruited T cells established stable interactions with and killed antigen-bearing dendritic cells, limiting the ability of these dendritic cells to activate naive CD4+ and CD8+ T cells. The inducible recruitment of blood-borne effector and memory T cells to lymph nodes may represent a mechanism for terminating primary and limiting secondary immune responses.
nature.com