Combined Tlr2 and Tlr4 deficiency increases radiation-induced pulmonary fibrosis in mice
A Paun, J Fox, V Balloy, M Chignard, ST Qureshi… - International Journal of …, 2010 - Elsevier
PURPOSE: To determine whether Toll-like receptor 2 or 4 genotype alters the lung response
to irradiation in C57BL/6 mice using a model developing a phenotype that resembles
radiotherapy-induced fibrosis in both histological characteristics and onset post-treatment.
METHODS AND MATERIALS: The pulmonary phenotype of C57BL/6 mice deficient in each
or both of these genes was assessed after an 18-Gy single dose to the thoracic cavity by
survival time postirradiation, bronchoalveolar lavage cell differential, histological evidence of …
to irradiation in C57BL/6 mice using a model developing a phenotype that resembles
radiotherapy-induced fibrosis in both histological characteristics and onset post-treatment.
METHODS AND MATERIALS: The pulmonary phenotype of C57BL/6 mice deficient in each
or both of these genes was assessed after an 18-Gy single dose to the thoracic cavity by
survival time postirradiation, bronchoalveolar lavage cell differential, histological evidence of …