[HTML][HTML] Analysis of CD44-hyaluronan interactions in an artificial membrane system: insights into the distinct binding properties of high and low molecular weight …
PM Wolny, S Banerji, C Gounou, AR Brisson… - Journal of Biological …, 2010 - ASBMB
CD44 is a major cell surface receptor for the large polydisperse glycosaminoglycan
hyaluronan (HA). Binding of the long and flexible HA chains is thought to be stabilized by the
multivalent nature of the sugar molecule. In addition, high and low molecular weight forms of
HA provoke distinct proinflammatory and anti-inflammatory effects upon binding to CD44
and can deliver either proliferative or antiproliferative signals in appropriate cell types.
Despite the importance of such interactions, however, neither the stoichiometry of …
hyaluronan (HA). Binding of the long and flexible HA chains is thought to be stabilized by the
multivalent nature of the sugar molecule. In addition, high and low molecular weight forms of
HA provoke distinct proinflammatory and anti-inflammatory effects upon binding to CD44
and can deliver either proliferative or antiproliferative signals in appropriate cell types.
Despite the importance of such interactions, however, neither the stoichiometry of …
