The chemo-and radioresponse of tumor cells can be determined by genetic factors (eg,
those that modify cell cycle arrest, DNA damage repair or cell death) and
microenvironmental factors, such as hypoxia. Poly (ADP-ribose) polymerase (PARP) is a
nuclear enzyme that rapidly recognizes and binds to DNA breaks to facilitate DNA strand
break repair. Pre-clinical data suggest that PARP inhibitors (PARPi) may potentiate the
effects of radiotherapy and chemotherapy. However, it is unclear as to whether PARPi are …