[HTML][HTML] Apoptosis signal-regulating kinase (ASK) 2 functions as a mitogen-activated protein kinase kinase kinase in a heteromeric complex with ASK1
K Takeda, R Shimozono, T Noguchi, T Umeda… - Journal of Biological …, 2007 - ASBMB
Apoptosis signal-regulating kinase (ASK) 1 is a mitogen-activated protein kinase kinase
kinase (MAP3K) in the c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein
kinase pathways that play multiple important roles in cytokine and stress responses. Here
we show that ASK2, a highly related serine/threonine kinase to ASK1, also functions as a
MAP3K only in a heteromeric complex with ASK1. We found that endogenous ASK2 was
constitutively degraded in ASK1-deficient cells, suggesting that ASK1 is required for the …
kinase (MAP3K) in the c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein
kinase pathways that play multiple important roles in cytokine and stress responses. Here
we show that ASK2, a highly related serine/threonine kinase to ASK1, also functions as a
MAP3K only in a heteromeric complex with ASK1. We found that endogenous ASK2 was
constitutively degraded in ASK1-deficient cells, suggesting that ASK1 is required for the …