Transforming growth factor-β signaling is constantly shaping memory T-cell population

C Ma, N Zhang - Proceedings of the National Academy of …, 2015 - National Acad Sciences
C Ma, N Zhang
Proceedings of the National Academy of Sciences, 2015National Acad Sciences
The long-term maintenance of memory T cells is essential for successful vaccines. Both the
quantity and the quality of the memory T-cell population must be maintained. The signals
that control the maintenance of memory T cells remain incompletely identified. Here we used
two genetic models to show that continuous transforming growth factor-β signaling to
antigen-specific T cells is required for the differentiation and maintenance of memory CD8+
T cells. In addition, both infection-induced and microbiota-induced inflammation impact the …
The long-term maintenance of memory T cells is essential for successful vaccines. Both the quantity and the quality of the memory T-cell population must be maintained. The signals that control the maintenance of memory T cells remain incompletely identified. Here we used two genetic models to show that continuous transforming growth factor-β signaling to antigen-specific T cells is required for the differentiation and maintenance of memory CD8+ T cells. In addition, both infection-induced and microbiota-induced inflammation impact the phenotypic and functional identity of memory CD8+ T cells.
National Acad Sciences