[PDF][PDF] Wnt/β-catenin signaling: components, mechanisms, and diseases

BT MacDonald, K Tamai, X He - Developmental cell, 2009 - cell.com
BT MacDonald, K Tamai, X He
Developmental cell, 2009cell.com
Signaling by the Wnt family of secreted glycolipoproteins via the transcriptional coactivator β-
catenin controls embryonic development and adult homeostasis. Here we review recent
progress in this so-called canonical Wnt signaling pathway. We discuss Wnt ligands,
agonists, and antagonists, and their interactions with Wnt receptors. We also dissect critical
events that regulate β-catenin stability, from Wnt receptors to the cytoplasmic β-catenin
destruction complex, and nuclear machinery that mediates β-catenin-dependent …
Signaling by the Wnt family of secreted glycolipoproteins via the transcriptional coactivator β-catenin controls embryonic development and adult homeostasis. Here we review recent progress in this so-called canonical Wnt signaling pathway. We discuss Wnt ligands, agonists, and antagonists, and their interactions with Wnt receptors. We also dissect critical events that regulate β-catenin stability, from Wnt receptors to the cytoplasmic β-catenin destruction complex, and nuclear machinery that mediates β-catenin-dependent transcription. Finally, we highlight some key aspects of Wnt/β-catenin signaling in human diseases including congenital malformations, cancer, and osteoporosis, and discuss potential therapeutic implications.
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