[PDF][PDF] The rs2228145 polymorphism in the interleukin-6 receptor and its association with long-term prognosis after myocardial infarction in a pilot study

A Szpakowicz, W Pepinski, E Waszkiewicz… - Archives of Medical …, 2017 - termedia.pl
A Szpakowicz, W Pepinski, E Waszkiewicz, M Skawronska, A Niemcunowicz-Janica…
Archives of Medical Science, 2017termedia.pl
Results: The registry comprised 553 patients (mean age: 62.4±11.9 years; 25.6% females,
n= 142; TIMI 3 obtained in 91.7% of patients, n= 507). No significant differences in baseline
characteristics were found between the genotypes. During long-term follow-up 171 (30.9%)
patients died. There was non-significantly higher mortality in the rs2228145 AA
homozygotes compared to C allele carriers (OR= 1.34, 95% CI: 0.93–1.93, p= 0.1).
Conclusions: The rs2228145 polymorphism of IL6R was not significantly associated with …
Results: The registry comprised 553 patients (mean age: 62.4±11.9 years; 25.6% females, n= 142; TIMI 3 obtained in 91.7% of patients, n= 507). No significant differences in baseline characteristics were found between the genotypes. During long-term follow-up 171 (30.9%) patients died. There was non-significantly higher mortality in the rs2228145 AA homozygotes compared to C allele carriers (OR= 1.34, 95% CI: 0.93–1.93, p= 0.1).
Conclusions: The rs2228145 polymorphism of IL6R was not significantly associated with long-term mortality after STEMI. However, AA homozygotes (high-risk genotype for ischemic heart disease) showed a trend towards adverse outcome compared to C allele carriers. The observed trend is promising, but it requires independent replication studies.
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