[HTML][HTML] Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible …

GL Semenza, BH Jiang, SW Leung… - Journal of Biological …, 1996 - ASBMB
Hypoxia-inducible factor 1 (HIF-1) is a basic helix-loop-helix transcription factor which is
expressed when mammalian cells are subjected to hypoxia and which activates
transcription of genes encoding erythropoietin, vascular endothelial growth factor, and other
proteins that are important for maintaining oxygen homeostasis. Previous studies have
provided indirect evidence that HIF-1 also regulates transcription of genes encoding
glycolytic enzymes. In this paper we characterize hypoxia response elements in the …