Depending on the initiating stimulus, cancer cell death can be immunogenic or
nonimmunogenic. Immunogenic cell death (ICD) involves changes in the composition of the
cell surface as well as the release of soluble mediators, occurring in a defined temporal
sequence. Such signals operate on a series of receptors expressed by dendritic cells to
stimulate the presentation of tumor antigens to T cells. We postulate that ICD constitutes a
prominent pathway for the activation of the immune system against cancer, which in turn …