Chemokines and chemokine receptors: positioning cells for host defense and immunity
JW Griffith, CL Sokol, AD Luster - Annual review of immunology, 2014 - annualreviews.org
Chemokines are chemo tactic cyto kines that control the migratory patterns and positioning
of all immune cells. Although chemokines were initially appreciated as important mediators
of acute inflammation, we now know that this complex system of approximately 50
endogenous chemokine ligands and 20 G protein–coupled seven-transmembrane signaling
receptors is also critical for the generation of primary and secondary adaptive cellular and
humoral immune responses. Recent studies demonstrate important roles for the chemokine …
of all immune cells. Although chemokines were initially appreciated as important mediators
of acute inflammation, we now know that this complex system of approximately 50
endogenous chemokine ligands and 20 G protein–coupled seven-transmembrane signaling
receptors is also critical for the generation of primary and secondary adaptive cellular and
humoral immune responses. Recent studies demonstrate important roles for the chemokine …