[HTML][HTML] L-Ascorbic acid 6-hexadecanoate, a potent hyaluronidase inhibitor: X-Ray structure and molecular modeling of enzyme-inhibitor complexes
Hyaluronidases are enzymes that degrade hyaluronan, an important component of the
extracellular matrix. The mammalian hyaluronidases are considered to be involved in many
(patho) physiological processes like fertilization, tumor growth, and metastasis. Bacterial
hyaluronidases, also termed hyaluronate lyases, contribute to the spreading of
microorganisms in tissues. Such roles for hyaluronidases suggest that inhibitors could be
useful pharmacological tools. Potent and selective inhibitors are not known to date, although …
extracellular matrix. The mammalian hyaluronidases are considered to be involved in many
(patho) physiological processes like fertilization, tumor growth, and metastasis. Bacterial
hyaluronidases, also termed hyaluronate lyases, contribute to the spreading of
microorganisms in tissues. Such roles for hyaluronidases suggest that inhibitors could be
useful pharmacological tools. Potent and selective inhibitors are not known to date, although …