[PDF][PDF] Phenylephrine promotes cardiac fibroblast proliferation through calcineurin-NFAT pathway.
J Wang, Y Wang, W Zhang, X Zhao, X Chen… - …, 2016 - article.imrpress.com
J Wang, Y Wang, W Zhang, X Zhao, X Chen, W Xiao, L Zhang, Y Chen, W Zhu
development, 2016•article.imrpress.com1. ABSTRACT Ca2+/calmodulin-dependent calcineurin (CaN) plays an important role in
various Ca2+ signaling pathways, among which are those involved in cardiac diseases. It
has also been shown that a heightened sympathetic tone accelerates the development of
heart failure. The present study investigates whether the CaN-mediated nuclear factor of
activated T-cells (NFAT) pathway is involved in cultured neonatal rat cardiac fibroblast
proliferation induced by phenylephrine. CF proliferation was assessed by a cell survival …
various Ca2+ signaling pathways, among which are those involved in cardiac diseases. It
has also been shown that a heightened sympathetic tone accelerates the development of
heart failure. The present study investigates whether the CaN-mediated nuclear factor of
activated T-cells (NFAT) pathway is involved in cultured neonatal rat cardiac fibroblast
proliferation induced by phenylephrine. CF proliferation was assessed by a cell survival …
Abstract
Ca2+/calmodulin-dependent calcineurin (CaN) plays an important role in various Ca2+ signaling pathways, among which are those involved in cardiac diseases. It has also been shown that a heightened sympathetic tone accelerates the development of heart failure. The present study investigates whether the CaN-mediated nuclear factor of activated T-cells (NFAT) pathway is involved in cultured neonatal rat cardiac fibroblast proliferation induced by phenylephrine. CF proliferation was assessed by a cell survival assay and cell counts. Green fluorescent protein-tagged NFAT3 was used to determine the cellular location of NFAT3. CaN activity and protein levels were also determined by
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