Poly (adenosine diphosphate-ribose) polymerase expression in BRCA-proficient ovarian high-grade serous carcinoma; association with patient survival
A Gan, AR Green, CC Nolan, S Martin, S Deen - Human pathology, 2013 - Elsevier
Ovarian cancers with BRCA mutations rely on the alternative DNA repair mechanism of the
poly (adenosine diphosphate-ribose) polymerases (PARP)–dependent base excision repair
pathway, with a better overall survival and response to chemotherapy, than BRCA1-
proficient cases. This can be enhanced further by using PARP inhibitors. Rate of PARP
cleavage may have an independent role from BRCA in contributing to response to
chemotherapy. We hypothesize that, regardless of BRCA profile, high expression of PARP1 …
poly (adenosine diphosphate-ribose) polymerases (PARP)–dependent base excision repair
pathway, with a better overall survival and response to chemotherapy, than BRCA1-
proficient cases. This can be enhanced further by using PARP inhibitors. Rate of PARP
cleavage may have an independent role from BRCA in contributing to response to
chemotherapy. We hypothesize that, regardless of BRCA profile, high expression of PARP1 …