[HTML][HTML] Poly (ADP-ribose) polymerase activity prevents signaling pathways for cell cycle arrest after DNA methylating agent exposure
JK Horton, DF Stefanick, JM Naron, PS Kedar… - Journal of Biological …, 2005 - ASBMB
Mouse fibroblasts, deficient in DNA polymerase β, are hypersensitive to monofunctional
DNA methylating agents such as methyl methanesulfonate (MMS). Both wild-type and, in
particular, repair-deficient DNA polymerase β null cells are highly sensitized to the cytotoxic
effects of MMS by 4-amino-1, 8-naphthalimide (4-AN), an inhibitor of poly (ADP-ribose)
polymerase (PARP) activity. Experiments with synchronized cells suggest that exposure
during S-phase of the cell cycle is required for the 4-AN effect. 4-AN elicits a similar extreme …
DNA methylating agents such as methyl methanesulfonate (MMS). Both wild-type and, in
particular, repair-deficient DNA polymerase β null cells are highly sensitized to the cytotoxic
effects of MMS by 4-amino-1, 8-naphthalimide (4-AN), an inhibitor of poly (ADP-ribose)
polymerase (PARP) activity. Experiments with synchronized cells suggest that exposure
during S-phase of the cell cycle is required for the 4-AN effect. 4-AN elicits a similar extreme …