PI3K/Akt: getting it right matters

TF Franke - Oncogene, 2008 - nature.com
Oncogene, 2008nature.com
The Akt serine/threonine kinase (also called protein kinase B) has emerged as a critical
signaling molecule within eukaryotic cells. Significant progress has been made in clarifying
its regulation by upstream kinases and identifying downstream mechanisms that mediate its
effects in cells and contribute to signaling specificity. Here, we provide an overview of
present advances in the field regarding the function of Akt in physiological and pathological
cell function within a more generalized framework of Akt signal transduction. An emphasis is …
Abstract
The Akt serine/threonine kinase (also called protein kinase B) has emerged as a critical signaling molecule within eukaryotic cells. Significant progress has been made in clarifying its regulation by upstream kinases and identifying downstream mechanisms that mediate its effects in cells and contribute to signaling specificity. Here, we provide an overview of present advances in the field regarding the function of Akt in physiological and pathological cell function within a more generalized framework of Akt signal transduction. An emphasis is placed on the involvement of Akt in human diseases ranging from cancer to metabolic dysfunction and mental disease.
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