Necroptosis in development, inflammation and disease

R Weinlich, A Oberst, HM Beere… - Nature reviews Molecular …, 2017 - nature.com
R Weinlich, A Oberst, HM Beere, DR Green
Nature reviews Molecular cell biology, 2017nature.com
In the early 2000s, receptor-interacting serine/threonine protein kinase 1 (RIPK1), a
molecule already recognized as an important regulator of cell survival, inflammation and
disease, was attributed an additional function: the regulation of a novel cell death pathway
that came to be known as necroptosis. Subsequently, the related kinase RIPK3 and its
substrate mixed-lineage kinase domain-like protein (MLKL) were also implicated in the
necroptotic pathway, and links between this pathway and apoptosis were established. In this …
Abstract
In the early 2000s, receptor-interacting serine/threonine protein kinase 1 (RIPK1), a molecule already recognized as an important regulator of cell survival, inflammation and disease, was attributed an additional function: the regulation of a novel cell death pathway that came to be known as necroptosis. Subsequently, the related kinase RIPK3 and its substrate mixed-lineage kinase domain-like protein (MLKL) were also implicated in the necroptotic pathway, and links between this pathway and apoptosis were established. In this Timeline article, we outline the discoveries that have helped to identify the roles of RIPK1, RIPK3, MLKL and other regulators of necroptosis, and how they interact to determine cell fate.
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