Secreted aspartic protease 2 of Candida albicans inactivates factor H and the macrophage factor H-receptors CR3 (CD11b/CD18) and CR4 (CD11c/CD18)
E Svoboda, AE Schneider, N Sándor, U Lermann… - Immunology letters, 2015 - Elsevier
The opportunistic pathogenic yeast Candida albicans employs several mechanisms to
interfere with the human complement system. This includes the acquisition of host
complement regulators, the release of molecules that scavenge complement proteins or
block cellular receptors, and the secretion of proteases that inactivate complement
components. Secreted aspartic protease 2 (Sap2) was previously shown to cleave C3b, C4b
and C5. C. albicans also recruits the complement inhibitor factor H (FH), but yeast-bound FH …
interfere with the human complement system. This includes the acquisition of host
complement regulators, the release of molecules that scavenge complement proteins or
block cellular receptors, and the secretion of proteases that inactivate complement
components. Secreted aspartic protease 2 (Sap2) was previously shown to cleave C3b, C4b
and C5. C. albicans also recruits the complement inhibitor factor H (FH), but yeast-bound FH …