We have assessed characteristics of primary human osteoblasts, shedding light on signaling
mediated by β 1 integrin. β 1 integrins are major receptors for these matrix glycoproteins. 1)
Integrins β 1, α 2, α 3, α 4, α 5, α 6, and α v were highly expressed on primary osteoblasts. 2)
Engagement of β 1 integrins on osteoblasts by cross-linking with specific antibody or ligand
matrices, such as fibronectin or collagen, augmented expression of intercellular adhesion
molecule 1 (ICAM-1) and receptor activator of nuclear factor κB ligand (RANKL) on the …