Plasminogen activator inhibitor 1: physiological and pathophysiological roles
BR Binder, G Christ, F Gruber, N Grubic… - …, 2002 - journals.physiology.org
Physiology, 2002•journals.physiology.org
Plasminogen activator inhibitor 1 (PAI-1) inhibits plasminogen activators (u-PA and t-PA) by
forming stable complexes endocytosed via a low-density lipoprotein receptor superfamily
member-dependent mechanism. PAI-1 circulates actively in plasma and latently in platelets
but is also secreted and deposited into the matrix by several cells, where it participates in
tissue repair processes.
forming stable complexes endocytosed via a low-density lipoprotein receptor superfamily
member-dependent mechanism. PAI-1 circulates actively in plasma and latently in platelets
but is also secreted and deposited into the matrix by several cells, where it participates in
tissue repair processes.
Plasminogen activator inhibitor 1 (PAI-1) inhibits plasminogen activators (u-PA and t-PA) by forming stable complexes endocytosed via a low-density lipoprotein receptor superfamily member-dependent mechanism. PAI-1 circulates actively in plasma and latently in platelets but is also secreted and deposited into the matrix by several cells, where it participates in tissue repair processes.
American Physiological Society