Association of elevated plasminogen activator inhibitor 1 levels with diminished lung function in patients with asthma
S Cho, J Kang, C Lyttle, K Harris, B Daley… - Annals of Allergy …, 2011 - Elsevier
Background We previously reported that plasminogen activator inhibitor 1 (PAI-1) was
upregulated in human asthmatic airways and promotes airway fibrosis in an allergen-
challenged murine model of asthma. Objectives To examine whether elevated plasma levels
of PAI-1 are associated with poor lung function in asthmatic patients. Methods Five hundred
nineteen adults were eligible for the study, and ultimately 353 adults were enrolled and
completed the baseline protocol between January 24, 2004, and July 30, 2005. Of these …
upregulated in human asthmatic airways and promotes airway fibrosis in an allergen-
challenged murine model of asthma. Objectives To examine whether elevated plasma levels
of PAI-1 are associated with poor lung function in asthmatic patients. Methods Five hundred
nineteen adults were eligible for the study, and ultimately 353 adults were enrolled and
completed the baseline protocol between January 24, 2004, and July 30, 2005. Of these …