Regulation of endonuclease activity in human nucleotide excision repair
AF Fagbemi, B Orelli, OD Schärer - DNA repair, 2011 - Elsevier
Nucleotide excision repair (NER) is a DNA repair pathway that is responsible for removing a
variety of lesions caused by harmful UV light, chemical carcinogens, and environmental
mutagens from DNA. NER involves the concerted action of over 30 proteins that sequentially
recognize a lesion, excise it in the form of an oligonucleotide, and fill in the resulting gap by
repair synthesis. ERCC1–XPF and XPG are structure-specific endonucleases responsible
for carrying out the incisions 5′ and 3′ to the damage respectively, culminating in the …
variety of lesions caused by harmful UV light, chemical carcinogens, and environmental
mutagens from DNA. NER involves the concerted action of over 30 proteins that sequentially
recognize a lesion, excise it in the form of an oligonucleotide, and fill in the resulting gap by
repair synthesis. ERCC1–XPF and XPG are structure-specific endonucleases responsible
for carrying out the incisions 5′ and 3′ to the damage respectively, culminating in the …