Actions of intrathecal diphtheria toxin-substance P fusion protein on models of persistent pain
R Benoliel, E Eliav, AJ Mannes, RM Caudle, S Leeman… - Pain, 1999 - Elsevier
Substance P (SP) plays a central role in the transduction of second messenger signals from
primary afferent nociceptive terminals to second-order neurons in the spinal cord. We have
tested a recombinant engineered diphtheria toxin/SP fusion protein (DAB389SP) in acute
and chronic pain models in the rat. DAB389SP binds to the SP receptor (SPR) and is
internalized and kills SPR-expressing cells by blocking cellular protein synthesis.
DAB389SP delivery was by intrathecal infusion, of varying duration, at the lumbar level. In …
primary afferent nociceptive terminals to second-order neurons in the spinal cord. We have
tested a recombinant engineered diphtheria toxin/SP fusion protein (DAB389SP) in acute
and chronic pain models in the rat. DAB389SP binds to the SP receptor (SPR) and is
internalized and kills SPR-expressing cells by blocking cellular protein synthesis.
DAB389SP delivery was by intrathecal infusion, of varying duration, at the lumbar level. In …