[HTML][HTML] Hepatic lipase promotes the selective uptake of high density lipoprotein-cholesteryl esters via the scavenger receptor B1
G Lambert, MB Chase, K Dugi, A Bensadoun… - Journal of lipid …, 1999 - ASBMB
Hepatic lipase (HL) plays a major role in high-density lipoprotein (HDL) metabolism both as
a lipolytic enzyme and as a ligand. To investigate whether HL enhances the uptake of HDL-
cholesteryl ester (CE) via the newly described scavenger receptor BI (SR-BI), we measured
the effects of expressing HL and SR-BI on HDL-cell association as well as uptake of 125 I-
labeled apoA-I and [3 H] CE-HDL, by embryonal kidney 293 cells. As expected, HDL cell
association and CE selective uptake were increased in SR-BI transfected cells by 2-and 4 …
a lipolytic enzyme and as a ligand. To investigate whether HL enhances the uptake of HDL-
cholesteryl ester (CE) via the newly described scavenger receptor BI (SR-BI), we measured
the effects of expressing HL and SR-BI on HDL-cell association as well as uptake of 125 I-
labeled apoA-I and [3 H] CE-HDL, by embryonal kidney 293 cells. As expected, HDL cell
association and CE selective uptake were increased in SR-BI transfected cells by 2-and 4 …