[HTML][HTML] Increased risk of atherosclerosis by elevated plasma levels of phospholipid transfer protein
R van Haperen, A van Tol, T van Gent, L Scheek… - Journal of Biological …, 2002 - ASBMB
Plasma phospholipid transfer protein (PLTP) is thought to be involved in the remodeling of
high density lipoproteins (HDL), which are atheroprotective. It is also involved in the
metabolism of very low density lipoproteins (VLDL). Hence, PLTP is thought to be an
important factor in lipoprotein metabolism and the development of atherosclerosis. We have
overexpressed PLTP in mice heterozygous for the low density lipoprotein (LDL) receptor, a
model for atherosclerosis. We show that increased PLTP activity results in a dose …
high density lipoproteins (HDL), which are atheroprotective. It is also involved in the
metabolism of very low density lipoproteins (VLDL). Hence, PLTP is thought to be an
important factor in lipoprotein metabolism and the development of atherosclerosis. We have
overexpressed PLTP in mice heterozygous for the low density lipoprotein (LDL) receptor, a
model for atherosclerosis. We show that increased PLTP activity results in a dose …