[HTML][HTML] Mild Dyslipidemia in Mice following Targeted Inactivation of the Hepatic Lipase Gene (∗)
GE Homanics, HV de Silva, J Osada, SH Zhang… - Journal of Biological …, 1995 - ASBMB
In order to gain better understanding of the function of hepatic lipase (HL) in vivo, we have
generated mice that lack HL using gene targeting in embryonic stem cells. No mRNA for HL
was detected in the liver of homozygous mutants, and no HL activity was detected in their
plasma. Total cholesterol levels in plasma of mutant mice were increased by about 30%
compared with wild type animals. Plasma phospholipids and high density lipoprotein (HDL)
cholesterol were also increased, but plasma levels of triglycerides were not altered. Analysis …
generated mice that lack HL using gene targeting in embryonic stem cells. No mRNA for HL
was detected in the liver of homozygous mutants, and no HL activity was detected in their
plasma. Total cholesterol levels in plasma of mutant mice were increased by about 30%
compared with wild type animals. Plasma phospholipids and high density lipoprotein (HDL)
cholesterol were also increased, but plasma levels of triglycerides were not altered. Analysis …