[HTML][HTML] Hepatic lipase facilitates the selective uptake of cholesteryl esters from remnant lipoproteins in apoE-deficient mice
MJA Amar, KA Dugi, CC Haudenschild… - Journal of lipid …, 1998 - ASBMB
We have investigated the role of hepatic lipase (HL) in remnant lipoprotein metabolism
independent of lipolysis by using recombinant adenovirus to express native and catalytically
inactive HL (HL-145G) in apolipoprotein (apo) E-deficient mice characterized by increased
plasma concentrations of apoB-48-containing remnants. In the absence of apoE, the
mechanisms by which apoB-48-containing remnants are taken up by either low density
lipoprotein (LDL)-receptor or LDL-receptor-related protein (LRP) remain unclear …
independent of lipolysis by using recombinant adenovirus to express native and catalytically
inactive HL (HL-145G) in apolipoprotein (apo) E-deficient mice characterized by increased
plasma concentrations of apoB-48-containing remnants. In the absence of apoE, the
mechanisms by which apoB-48-containing remnants are taken up by either low density
lipoprotein (LDL)-receptor or LDL-receptor-related protein (LRP) remain unclear …