Hepatic lipase (HL) plays a role in the metabolism of pro-and anti-atherogenic lipoproteins
affecting their plasma level and composition. However, there is controversy regarding
whether HL accelerates or retards atherosclerosis. Its effects on different lipoprotein classes
show that, potentially, HL may promote as well as decrease atherogenesis. Studies in
animals with genetically modulated HL expression show that it depends on the model used
whether HL acts pro-or anti-atherogenic. In humans, HL activity seems to correlate inversely …