FoxO transcription factors are important targets of insulin action. To better understand the
role of FoxO proteins in the liver, we created transgenic mice expressing constitutively active
FoxO1 in the liver using the α1-antitrypsin promoter. Fasting glucose levels are increased,
and glucose tolerance is impaired in transgenic (TGN) versus wild type (WT) mice.
Interestingly, fasting triglyceride and cholesterol levels are reduced despite
hyperinsulinemia, and post-prandial changes in triglyceride levels are markedly suppressed …