[HTML][HTML] R-spondin1 is a high affinity ligand for LRP6 and induces LRP6 phosphorylation and β-catenin signaling
R-spondin proteins are newly identified secreted molecules that activate β-catenin signaling.
However, the mechanism of R-spondin action and its relationship with Wnt signaling remain
unclear. Here we show that human R-spondin1 (hRspo1) is a high affinity ligand for the Wnt
co-receptor LRP6 (K d= 1.2 nm). hRspo1 induces glycogen synthase kinase 3-dependent
phosphorylation and activation of LRP6. DKK1, an LRP6 antagonist, inhibits hRspo1-
induced LRP6 phosphorylation. We further demonstrate that hRspo1 synergizes with …
However, the mechanism of R-spondin action and its relationship with Wnt signaling remain
unclear. Here we show that human R-spondin1 (hRspo1) is a high affinity ligand for the Wnt
co-receptor LRP6 (K d= 1.2 nm). hRspo1 induces glycogen synthase kinase 3-dependent
phosphorylation and activation of LRP6. DKK1, an LRP6 antagonist, inhibits hRspo1-
induced LRP6 phosphorylation. We further demonstrate that hRspo1 synergizes with …