[HTML][HTML] Selective insulin resistance in adipocytes
Aside from glucose metabolism, insulin regulates a variety of pathways in peripheral tissues.
Under insulin-resistant conditions, it is well known that insulin-stimulated glucose uptake is
impaired, and many studies attribute this to a defect in Akt signaling. Here we make use of
several insulin resistance models, including insulin-resistant 3T3-L1 adipocytes and fat
explants prepared from high fat-fed C57BL/6J and ob/ob mice, to comprehensively
distinguish defective from unaffected aspects of insulin signaling and its downstream …
Under insulin-resistant conditions, it is well known that insulin-stimulated glucose uptake is
impaired, and many studies attribute this to a defect in Akt signaling. Here we make use of
several insulin resistance models, including insulin-resistant 3T3-L1 adipocytes and fat
explants prepared from high fat-fed C57BL/6J and ob/ob mice, to comprehensively
distinguish defective from unaffected aspects of insulin signaling and its downstream …