[HTML][HTML] Renal endothelial protein C receptor expression and shedding during diabetic nephropathy
L Lattenist, P Ochodnický, M Ahdi, N Claessen… - Journal of Thrombosis …, 2016 - Elsevier
Essentials• Endothelial protein C receptor (EPCR) promotes diabetic nephropathy (DN)
outcome improvement.• Renal expression and shedding of EPCR were measured in
diabetic patients with or without DN.• Inhibition of metalloproteinase‐driven EPCR shedding
restored glomerular endothelium phenotype.• EPCR shedding through metalloproteinase
ADAM17 contributes to the worsening of DN. Summary: Background Diabetic nephropathy
(DN) represents the leading cause of end‐stage renal disease. The endothelial protein C …
outcome improvement.• Renal expression and shedding of EPCR were measured in
diabetic patients with or without DN.• Inhibition of metalloproteinase‐driven EPCR shedding
restored glomerular endothelium phenotype.• EPCR shedding through metalloproteinase
ADAM17 contributes to the worsening of DN. Summary: Background Diabetic nephropathy
(DN) represents the leading cause of end‐stage renal disease. The endothelial protein C …