Telomere attrition of the human abdominal aorta: relationships with age and atherosclerosis
K Okuda, MY Khan, J Skurnick, M Kimura, H Aviv… - Atherosclerosis, 2000 - Elsevier
Little is known about the turnover rate (ie the rate of replication and death) of cells in the
intima and media of human arteries as a function of age and atherosclerosis. One indicator
of the replicative history of cells is telomere length. In this work we explored the rate of
telomere attrition as a function of age and atherosclerosis in cells of the human abdominal
aorta. Telomere length, measured by the terminal restriction fragment using Southern
analysis, was determined in the intima and media of the distal (infrarenal) versus proximal …
intima and media of human arteries as a function of age and atherosclerosis. One indicator
of the replicative history of cells is telomere length. In this work we explored the rate of
telomere attrition as a function of age and atherosclerosis in cells of the human abdominal
aorta. Telomere length, measured by the terminal restriction fragment using Southern
analysis, was determined in the intima and media of the distal (infrarenal) versus proximal …